FIGURE

Fig 6

ID

ZDB-FIG-190723-1257

Publication

Lessieur et al., 2019 - Ciliary genes arl13b, ahi1 and cc2d2a differentially modify expression of visual acuity phenotypes but do not enhance retinal degeneration due to mutation of cep290 in zebrafish

Other Figures

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Fig 6

Mislocalization of rhodopsin in cep290^fh297/fh297 mutants.

(A-D) Images show cryosections labeled with Zpr3 (red) to mark rhodopsin and DAPI (blue) to label nuclei in the dorsal retinas from cep290^fh297/fh297 mutants and wild-type siblings at 3 months of age; (E-H) 6 months of age, and (I-L) 12 months of age. At later ages, the distance between the base of the rod outer segments and the outer nuclear layer decreases due to loss of cone nuclei (I, J; white brackets). Arrowheads note rhodopsin mislocalization. ROS, rod outer segments; COS, cone outer segments; CIS, cone inner segments; ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer. Scale bar: 100 μm.

Expression Data

Antibody:	zpr-3
Fish:	WT cep290^fh297/fh297
Anatomical Terms:	photoreceptor inner segment layer retinal rod cell rod photoreceptor outer segment
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cep290^fh297/fh297
Observed In:	photoreceptor inner segment layer retinal cone cell
Stage:	Adult

Phenotype Detail

Acknowledgments

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