FIGURE

Fig 4

ID

ZDB-FIG-190723-1255

Publication

Lessieur et al., 2019 - Ciliary genes arl13b, ahi1 and cc2d2a differentially modify expression of visual acuity phenotypes but do not enhance retinal degeneration due to mutation of cep290 in zebrafish

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Fig 4

Cone outer segment degeneration progresses with age in cep290^fh297/fh297mutants.

Immunohistochemistry of retinal cryosections stained with peanut agglutinin (PNA) to label cone outer segments and Zpr-1 (green) to label red/green double cones of wild-type and cep290^fh297/fh297 mutants. Views from dorsal retinas are shown. (A-F) Retinas from 3-month old adults. (G-L) Retinas from 6-month old adults. (M-R) Retinas from 12-month old adults. Arrows denote cones that were negative for PNA but positive for Zpr-1. ROS, rod outer segments; COS, cone outer segments; CIS, cone inner segments; ONL, outer nuclear layer; INL, inner nuclear layer; IPL, inner plexiform layer; GCL, ganglion cell layer. Scale bar: 50 μm.

Expression Data

Antibody:	zpr-1
Fish:	WT cep290^fh297/fh297
Anatomical Term:	retinal cone cell
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cep290^fh297/fh297
Observed In:	retinal cone cell retinal cone cell cone photoreceptor outer segment
Stage:	Adult

Phenotype Detail

Acknowledgments

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