FIGURE

Fig. 1

ID

ZDB-FIG-190715-19

Publication

Toms et al., 2019 - Phagosomal and mitochondrial alterations in RPE may contribute to KCNJ13 retinopathy

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Fig. 1

Retinal structure and function in obe^td15 zebrafish. (a) Wholemount morphology of adult wild-type (WT) and obe^td15zebrafish. (b) Retinal histology of obe^td15 zebrafish at 3, 6 and 12 months post fertilization (mpf). (c) Expression of kcnj13mRNA (green) in the WT adult zebrafish retina detected using an RNAscope assay. Sections are counterstained with DAPI nucleic acid stain (blue). (d) Visual acuity (cycles per degree) of obe^td15 zebrafish at 3, 6 and 12 mpf, measured using optokinetic response assay (minimum n = 4, mean ± SEM). (e) Retinal thickness (µm) of obe^td15 zebrafish at 3, 6 and 12 mpf, measured using OCT (n = 5 for each age, mean ± SEM). GCL, ganglion cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer; IS/OS, outer and inner segments; RPE, retinal pigment epithelium. *p < 0.05, **p < 0.01. Scale bars = 50 μm (b) and 25 μm (c).

Expression Data

Gene:	kcnj13
Fish:	AB
Anatomical Terms:	retinal ganglion cell layer retinal outer nuclear layer retinal outer plexiform layer retinal pigmented epithelium
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	kcnj13^td15/td15
Observed In:	retina retinal photoreceptor layer retinal pigmented epithelium
Stage:	Adult

Phenotype Detail

Acknowledgments

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