FIGURE

Fig. 4

ID

ZDB-FIG-190711-32

Publication

Cenedese et al., 2017 - Pannexin 1 Is Critically Involved in Feedback from Horizontal Cells to Cones

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Fig. 4

Light induced feedback responses in cones. Cones were saturated with a small spot of light and voltage clamped at −50 mV. A full field white light stimulus was applied. This resulted a small inward current: the light induced feedback response. (A) The black traces represent the mean light induced feedback response in WT. The red traces show the mean response of the various mutants. When Panx1a or Panx1b was mutated, feedback responses reduce but seem to keep a fast light-onset response. However, in the Cx55.5^−/−/Panx1a^−/− animals the response on-set seems to be slowed down. (B) Quantification of the sustained feedback response for all the mutants. All mutants showed a significantly reduced feedback response. *p < 0.05.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	panx1a^nhi6/nhi6 panx1b^nhi7/nhi7 gja9a^{hu1795/hu1795}; panx1a^nhi6/nhi6 panx1a^nhi6/nhi6; panx1b^nhi7/nhi7
Observed In:	retinal cone cell cellular response to light stimulus
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Mol. Neurosci.