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Fig. 4 Light induced feedback responses in cones. Cones were saturated with a small spot of light and voltage clamped at −50 mV. A full field white light stimulus was applied. This resulted a small inward current: the light induced feedback response. (A) The black traces represent the mean light induced feedback response in WT. The red traces show the mean response of the various mutants. When Panx1a or Panx1b was mutated, feedback responses reduce but seem to keep a fast light-onset response. However, in the Cx55.5−/−/Panx1a−/− animals the response on-set seems to be slowed down. (B) Quantification of the sustained feedback response for all the mutants. All mutants showed a significantly reduced feedback response. *p < 0.05.