FIGURE

Fig. S3

ID

ZDB-FIG-190624-28

Publication

Maerz et al., 2019 - Pharmacological cholesterol depletion disturbs ciliogenesis and ciliary function in developing zebrafish

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Fig. S3

a, Atorvastatin treatment results in embryos with curved bodies, which can be rescued by cholesterol. Live images at 48 hpf. Scale bar: 200 μm. b, Body curvature worsens by atorvastatin treatment and is improved upon cholesterol replenishment. Red line: median. n=3 experiments. *** p=0.0044, ns=0.0824, Kruskal-Wallis test with Dunn’s multiple comparison test. c, Live images of otic placodes at 48 hpf showing defects in otolith formation in atorvastatin treated embryos and regular otolith seeding in embryos co-treated with cholesterol. Scale bar: 50 μm. d, Graph displaying the percentage of otolith defects upon atorvastatin and concomitant cholesterol treatment and. Red line: median. n=3 experiments. * p=0.0295, ns: p=0.3125, Kruskal-Wallis test with Dunn’s multiple comparison test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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