FIGURE

Fig. S2

ID

ZDB-FIG-190108-47

Publication

Meireles et al., 2018 - The Lysosomal Transcription Factor TFEB Represses Myelination Downstream of the Rag-Ragulator Complex

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Fig. S2

Torin treated fish are developmentally delayed

mbp mRNA expression at 5 dpf as detected by whole mount in situ hybridization. Wildtype larvae treated with the mTOR signaling pathway inhibitor TORIN1 have delayed developmental progression and slightly reduced levels of mbp mRNA both in the CNS and PNS. Genotypes were determined by PCR after imaging. Scale bar = 50 μm.

Expression Data

Gene:	mbpa
Fish:	TL rraga^st77/st77 (TL)
Condition:	chemical treatment by environment: torin 1
Anatomical Terms:	central nervous system oligodendrocyte peripheral nervous system myelinating Schwann cell
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TL rraga^st77/st77 (TL)
Condition:	chemical treatment by environment: torin 1
Observed In:	central nervous system central nervous system myelination central nervous system oligodendrocyte embryo development peripheral nervous system myelinating Schwann cell peripheral nervous system myelination in peripheral nervous system
Stage:	Day 5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Cell, 47, Meireles, A.M., Shen, K., Zoupi, L., Iyer, H., Bouchard, E.L., Williams, A., Talbot, W.S., The Lysosomal Transcription Factor TFEB Represses Myelination Downstream of the Rag-Ragulator Complex, 319-330.e5, Copyright (2018) with permission from Elsevier. Full text @ Dev. Cell