FIGURE

Fig. 5

ID

ZDB-FIG-180917-28

Publication

Svahn et al., 2018 - Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons

Other Figures

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Fig. 5

Blebbing and TDP-43 mislocalisation in a motor neuron over the course of UV-induced degeneration after depletion of microglia. ai Cytoplasmic mTagBFP signal pre-irradiation. aii eGFP-TDP43^WT distribution in the soma of the neuron pre-irradiation. aiii Merged images. bi–iv eGFP-TDP43^WT signal redistributes into the cytoplasm and shows the blebbing of the cell soma during degeneration. Note the apparent fragmentation of the nucleus, in contrast to the concentration of nuclear eGFP-TDP43^WT in the previous figure. Scale = 2 µm

Expression Data

Genes:	EGFP TagBFP
Fish:	mq10Tg; mq14Tg + MO1-spi1b
Condition:	light damage: primary motor neuron
Knockdown Reagent:	MO1-spi1b
Anatomical Terms:	primary motor neuron cytoplasm primary motor neuron nucleus
Stage Range:	Protruding-mouth to Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mq10Tg; mq14Tg + MO1-spi1b
Condition:	light damage: primary motor neuron
Knockdown Reagent:	MO1-spi1b
Observed In:	microglial cell primary motor neuron primary motor neuron cytoplasm
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Acta Neuropathol.