FIGURE

Fig. 3

ID

ZDB-FIG-180828-79

Publication

Wang et al., 2018 - Triptolide attenuates proteinuria and podocyte apoptosis via inhibition of NF-κB/GADD45B

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Fig. 3

Triptolide reversed podocyte foot process effacement in MTZ-treated Tg(pod:gal4;UAS:NTR-mCherry) zebrafish. (A) Electron micrograph of normal glomerular vascular loop morphology and foot process development at 6 dpf in wild-type larvae. (B) Glomerular morphology of zebrafish treated with MTZ for 24 h. At low magnifications, an enlarged space outside of Bowman’s capsule was observed, indicating oedema (B1, indicated by #). Extensive foot process effacement was observed at higher magnifications (B3, indicated by arrows). (C) Triptolide prevented most foot process effacement. (n = 3). *Capillary that was magnified. podo, podocyte; cap, capillary space; BS, Bowman’s space; NC, notochord. Scale bar = 10 μm (A1,B1,C1), 2 μm (A2,B2,C2), 1 μm (A3,B3,C3).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mi1004Tg; rw0144Tg
Conditions:	chemical treatment by environment: metronidazole chemical treatment by environment: Triptolide
Observed In:	renal capsular space renal glomerulus podocyte foot
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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