FIGURE

Fig. 1

ID

ZDB-FIG-180724-66

Publication

Jain et al., 2018 - A Forward Genetic Screen in Zebrafish Identifies the G-Protein-Coupled Receptor CaSR as a Modulator of Sensorimotor Decision Making

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Fig. 1

Selection of Appropriate Behavioral Responses to Acoustic Stimuli Is a Dynamic Process

(A) Temporal projections over 40 ms post-stimulus of wild-type 5-dpf larvae performing SLC and LLC behaviors.

(B) Time course of the initial C-bend of wild-type (WIK) fish performing SLC and LLC responses, 16 dpf. Numbers show elapsed time (in milliseconds) after stimulus; red asterisks indicate active pectoral fin usage.

(C) Average behavioral bias (black, left axis) and response frequency (gray, right axis) of 48 larvae (5 dpf) to acoustic stimuli (p < 0.0001, Kruskal-Wallis test). Relative startle bias index was calculated for each larva at each intensity (see STAR Methods).

(D) Average relative startle bias of 5-dpf larvae following identical 26-dB stimuli at 20-s intervals (stimuli 1?10) and then 1-s intervals (stimuli 11?40).

(E) Average relative startle bias of 5-dpf larvae treated for 20 min with serotonin (5-HT) or dopamine D3 receptor agonist R-(+)-7-Hydroxy-DPAT (7OHD). Numbers of larvae tested are given at base of bars.

Error bars indicate SEM. See also Figures S1 and S2, Table S1, and Video S1.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WIK
Conditions:	chemical treatment by environment: serotonin chemical treatment by environment: dopamine agonist
Observed In:	auditory behavior
Stage:	Day 5

Phenotype Detail

Acknowledgments

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