FIGURE

Fig. 2

ID

ZDB-FIG-180622-4

Publication

Schepis et al., 2018 - Protease signaling regulates apical cell extrusion, cell contacts, and proliferation in epithelia

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Fig. 2

Par2b deficiency prevents grossly abnormal skin morphology in hai1a morphants. (A–D) Wild-type or par2b^−/− embryos were injected with the indicated MOs and imaged at 30 hpf. Images of control (A), hai1a morphant (B), par2b^−/−:hai1a morphant (C), and par2b^−/− embryos (D) are shown. Note the presence of cell clusters on hai1a morphants (B, arrowheads) and their absence on controls and Par2b-deficient hai1a morphants. Bar, 200 µm. (E) Percentage of embryos with cell clusters. 100 or more embryos were analyzed for each condition; mean ± SEM for three independent experiments is shown. Statistical analysis was performed using one-way ANOVA and Bonferroni posttest. The hai1a morphant was different from all other groups (P < 0.0001).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	f2rl1.2^{sfc18b/sfc18b} WT + MO1-spint1a f2rl1.2^{sfc18b/sfc18b} + MO1-spint1a WT + MO1-f2rl1.2 + MO1-spint1a WT + MO1-spint1a + MO1-st14a
Knockdown Reagents:	MO1-f2rl1.2 MO1-spint1a MO1-st14a
Observed In:	integument cell
Stage:	Prim-15

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cell Biol.