FIGURE

Fig. S4

ID

ZDB-FIG-180622-37

Publication

Missinato et al., 2018 - Dusp6 attenuates Ras/MAPK signaling to limit zebrafish heart regeneration

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Fig. S4

dusp6^pt30d/pt30d hearts show the same phenotype as dusp6^pt30a/pt30a (A) Whole-mount images of adult WT (n=32), dusp6^pt30a/pt30a (n=32), and dusp6^pt30d/pt30d (n=19) hearts at 7 dpa. dusp6 mutant hearts show cardiomegaly. A=Atrium; V=Ventricle; BA=Bulbus Arteriosus (B) Quantification of the ratio ventricle area/body weight (VA/BW). dusp6 mutant fish exhibit larger VA/BW than WT fish. ****p<0.0001; n.s.=not significant. One-way ANOVA. (C) Zebrafish hearts at 7 dpa, immunostained for Mef2c and PCNA. dusp6^pt30a/pt30a (n=29) and dusp6^pt30d/pt30d heart (n=14) show increased cardiomyocyte proliferation compared to WT hearts (n=33). (D) Quantification of cardiomyocyte proliferation index. ****p<0.0001. n.s.=not significant. One-way ANOVA. Scale bars, 100 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dusp6^pt30d/pt30d
Condition:	resection: cardiac ventricle
Observed In:	cardiac muscle cell proliferation
Stage:	Adult

Phenotype Detail

Acknowledgments

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