FIGURE

Fig. 5

ID

ZDB-FIG-180619-13

Publication

Gou et al., 2018 - sox2 and sox3 cooperate to regulate otic/epibranchial placode induction in zebrafish

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Fig. 5

Interaction betweenpax8-/-andsox3-/-during early placode development. (A-C) Expression of pax2a at 12 hpf in a wild-type control embryo (A), a pax8-/- mutant (B) and a pax8-/-; sox3-/- double mutant (C) embryo. Dorsal-lateral view with anterior to the left. Scale bar, 50 µm. (D) Box-and-whisker plot of relative surface area of otic/epibranchial domain of pax2a at 12 hpf in control, pax8-/- and pax8-/-; sox3-/- double mutant embryos. Data are normalized relative to control groups, with means indicated by green lines. Asterisks indicate statistically significant differences relative to controls (*** P<0.001, Tukey's HSD test). n.s., not significantly different.

Expression Data

Gene:	pax2a
Fish:	AB pax8^{nia03Gt/nia03Gt} (AB) sox3^x52/x52; pax8^{nia03Gt/nia03Gt} (AB)
Anatomical Term:	otic placode
Stage:	5-9 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pax8^{nia03Gt/nia03Gt} (AB) sox3^x52/x52; pax8^{nia03Gt/nia03Gt} (AB)
Observed In:	otic placode
Stage:	5-9 somites

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 435(1), Gou, Y., Guo, J., Maulding, K., Riley, B.B., sox2 and sox3 cooperate to regulate otic/epibranchial placode induction in zebrafish, 84-95, Copyright (2018) with permission from Elsevier. Full text @ Dev. Biol.