FIGURE

Fig. 6 S1

ID

ZDB-FIG-180207-26

Publication

LeBert et al., 2018 - Damage-induced reactive oxygen species regulate vimentin and dynamic collagen-based projections to mediate wound repair.

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Fig. 6 S1

Larp6-deficient larvae displayed reduced wound induced collagen expression.

(A) Early inhibition with WA led to reduced col1a1 and col2a1b expression at 24 hpw. (B) RT-PCR of larp6 knockdown via morpholino (see Materials and methods). (C) Larp6-deficient larvae displayed a reduction in col1a1 expression but no change in col2a1b expression at 24 hpw. (D) Larp6-deficient larvae exhibited a regenerate area defect at 2 dpw but not a regenerate length defect. Data in A and C represent data pooled from 4 replicate experiments and data in D represent a single experiment performed in triplicate. Scale bars represent 100 µm in D. *p<0.05, **p<0.01.

Expression Data

Genes:	col1a1a col2a1b
Fish:	AB AB + MO3-larp6a
Conditions:	chemical treatment: withaferin A, resection: caudal fin resection: caudal fin
Knockdown Reagent:	MO3-larp6a
Anatomical Term:	regenerating fin caudal fin
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB AB + MO3-larp6a
Conditions:	chemical treatment: withaferin A, resection: caudal fin resection: caudal fin
Knockdown Reagent:	MO3-larp6a
Observed In:	fin regeneration regenerating fin regenerating fin caudal fin
Stage Range:	Protruding-mouth to Day 4

Phenotype Detail

Acknowledgments

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