FIGURE

Fig. 6

ID

ZDB-FIG-180126-13

Publication

Facchinello et al., 2017 - Tcf7l2 plays pleiotropic roles in the control of glucose homeostasis, pancreas morphology, vascularization and regeneration

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Fig. 6

Defects in vascular endothelium and pancreas development of tcf7l2 ^exI/exI homozygous larvae. (A,B) Analysis of pancreatic islet and blood vessels inside and around the pancreas of tcf7l2 mutants and wild-type sib controls in Tg(fli1a:EGFP/ins:DsRed) background. Representative images were taken at 18 dpf by confocal microscopy at 20x magnification. (C) Graphic presentation of the integrated density of fluorescence in the red and green channel in tcf7l2 ^exI/exI mutant and wild-type sib controls at 18 dpf. The regions for the analysis of integrated density of fluorescence are indicated by white boxes. Data were obtained using Fiji software. (D) Analysis and graphic presentation of vessels diameter; the mutant is characterized by decreased vessel diameter. Data were obtained from five individuals per genotype. All reference to phenotypes was confirmed by genotyping; *p < 0.05.

Expression Data

Genes:	DsRed EGFP
Fish:	m1018Tg; y1Tg tcf7l2^zf55/zf55; m1018Tg; y1Tg
Anatomical Terms:	pancreas vasculature
Stage:	Days 14-20

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tcf7l2^zf55/zf55; m1018Tg; y1Tg
Observed In:	endocrine pancreas capillary
Stage:	Days 14-20

Phenotype Detail

Acknowledgments

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