FIGURE

Fig. 4

ID

ZDB-FIG-180118-42

Publication

Zabinyakov et al., 2017 - Characterization of the first knock-out aldh7a1 zebrafish model for pyridoxine-dependent epilepsy using CRISPR-Cas9 technology

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Fig. 4

EEG results of knock-out homozygous aldh7a1 embryos and wild type embryos at 9 dpf. A) This shows spike discharges in a homozygous with no response to 100 μM diazepam, but almost normalization of EEG on 25 mM pyridoxine compared to wild type. B) This shows another homozygous with no response to phenobarbital, but almost normalization of EEG on pyridoxine (25 mM) compared to wild type. C) This shows normal EEG with spikes on pentylenetetrazole, and normalization of EEG on diazepam.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT aldh7a1^{zf2074/zf2074}
Conditions:	chemical treatment: diazepam chemical treatment: pentetrazol chemical treatment: diazepam chemical treatment: phenobarbital chemical treatment: pyridoxine
Observed In:	regulation of neuronal action potential
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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