FIGURE

Fig. 8

ID

ZDB-FIG-180117-20

Publication

Pena et al., 2017 - Pyridoxine-Dependent Epilepsy in Zebrafish Caused by Aldh7a1 Deficiency

Other Figures

All Figure Page

Back to All Figure Page

Fig. 8

GABA levels are normalized by Pyr treatment but lysine metabolites are mostly unaffected in aldh7a1^−/− larvae. Mass spectrometry analysis of lysine metabolites in polar metabolite extracts was obtained from three pools of 11-days postfertilization larvae (six individuals each pool) per experimental condition; GABA (A), P6C (B), SAC (C), and PIP (D). Asterisks indicate statistical significance according to one-way ANOVA Tukey’s post hoc tests (* P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001). Error bars represent ± SD. GABA, γ-aminobutyric acid; P6C, piperideine-6-carboxylate; PIP, pipecolic acid; Pyr, pyridoxine; SAC, saccharopine; WT, wild-type.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	aldh7a1^ot100/ot100
Condition:	chemical treatment by environment: pyridoxine
Observed In:	whole organism 1-piperideine-6-carboxylic acid whole organism gamma-aminobutyric acid
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Genetics