FIGURE

Fig. 6

ID

ZDB-FIG-180117-18

Publication

Pena et al., 2017 - Pyridoxine-Dependent Epilepsy in Zebrafish Caused by Aldh7a1 Deficiency

Other Figures

All Figure Page

Back to All Figure Page

Fig. 6

Targeted mass spectrometry allowed the identification of several amino acid perturbations when comparing two different batches of aldh7a1-null mutants (Mut1 and Mut2) and their WT siblings (WT1 and WT2). (A) Graphical summary of one-way ANOVA analysis comparing the four groups of samples, using P-value cutoff of 0.05. Metabolites identified with statistically significant changes are shown in red and labeled. (B) box and whisker plots summarize the normalized values (mean fold change ± SD) for the metabolites shown in red in (B) significantly different between the two batches of WT and Mut. For this experiment, polar metabolite extracts of three pools (five 11-days postfertilization larvae each) were used for each group. GABA, γ-aminobutyric acid; P6C, piperideine 6-carboxylate; WT, wild-type.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	aldh7a1^ot100/ot100
Observed In:	whole organism 1-piperideine-6-carboxylic acid whole organism alpha-aminobutyric acid whole organism beta-alanine whole organism gamma-aminobutyric acid whole organism L-saccharopine whole organism methionine whole organism pipecolate whole organism serine whole organism taurine whole organism tyrosine
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Genetics