FIGURE

Fig. S1

ID

ZDB-FIG-170911-12

Publication

Santos-Ledo et al., 2017 - Kinesin-1 promotes chondrocyte maintenance during skeletal morphogenesis

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Fig. S1

Muscle phenotypes of kif5Blof mutants.

A-D) Ventral view of the anterior region of zebrafish at 5 dpf. Muscle fibers are shorter than Wt, and broken muscle fibers are detected along the body axis (arrows in C and D). This phenotype was not observed in kif5Ba single mutants (B). E-H) Lateral views of the tail at 5 dpf; broken muscle fibers are observed in kif5Blof mutants (arrows in G and H). I-L) Electron microscopy of the ocular muscle at 3 dpf (I, J) and 5 dpf (K, L). No disruption of muscle ultrastructure was apparent at 3 dpf (I, J). However, at 5 dpf the M-line of the sarcomere is diminished in kif5Blof mutants (I, J and insets).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	kif5ba^ae12/ae12; kif5bb^ae24/+ kif5ba^ae12/ae12; kif5bb^ae24/ae24
Observed In:	caudal fin skeletal muscle cell extraocular musculature M band trunk skeletal muscle cell
Stage:	Day 5

Phenotype Detail

Acknowledgments

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