FIGURE
Fig. 2
- ID
- ZDB-FIG-170825-19
- Publication
- Orr et al., 2016 - A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation
- Other Figures
- All Figure Page
- Back to All Figure Page
Fig. 2
Electrocardiograms and whole hearts from WT transgenic and E17K transgenic zebrafish. (a) WT transgenics exhibit a regular heart rate with electrocardiogram parameters typical for adult zebrafish. E17K transgenics display significantly slower sino-atrial activity and increased heart rate irregularity compared with controls. (b) Signal-averaged P-wave duration is prolonged in E17K transgenics, indicative of slower atrial conduction time. (c) Atrial area has been traced in isolated whole-WT transgenic and -E17K transgenic hearts (dotted lines), showing enlarged atrial chamber size in E17K transgenic. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
| Fish: | |
|---|---|
| Observed In: | |
| Stage: | Adult |
Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Full text @ Nat. Commun.