FIGURE

Fig. S7

ID

ZDB-FIG-170824-25

Publication

Chiang et al., 2017 - SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development

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Fig. S7

Partial Notch inhibition results in the loss of arterial identity in notch1b-15 endogenous mutant fish. (A) At 3dpf, notch1b-15^uq1mf/uq1mf mutant embryos treated with 5μM DAPT showed a significant reduction in the number of arterial connections (red arrowheads) between the dorsal longitudinal anastomotic vessel (DLAV) and dorsal aorta (DA), as indicated by the loss of YFP expression in the tg(fltYFP) background. (B) Quantification of YFP positive intersomitic vessels that connect between DLAV and DA in control (0μM DAPT) individual embryos at 3dpf. Vessels are labeled by tg(fltYFP). Mean ± SEM; scored sibling WT (+/+), n=3; Het (uq^1mf/+), n=18; Hom (uq^1mf/1mf), n=12; Mann-Whitney. (ns) No significant difference.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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