FIGURE

Fig. S5

ID

ZDB-FIG-170706-27

Publication

Pei et al., 2016 - Additive reductions in zebrafish PRPS1 activity result in a spectrum of deficiencies modeling several human PRPS1-associated diseases

Other Figures

All Figure Page

Back to All Figure Page

Fig. S5

Analysis of presynaptic ribbons and synapse of neuromast hair cells in the double mutant.

(A-C) Increased presynaptic ribbons in the double mutants. (A, B) Morphology of Ribeye stained presynaptic ribbons of neuromast hair cells in the control (A) and double mutant (B) embryos at 6 dpf. (C) Quantification of the number of presynaptic ribbons in the control and mutant embryos at 6 dpf, as well as in wild-type embryos at 4 dpf. (D-F) Increased synapses in the double mutants. (D,E) Morphology of Maguk stained synapses and Ribeye stained presynaptic ribbons of neuromast hair cells in the control (D) and double mutant (E) at 6 dpf. (F) Quantification of the number of synapses in the control and mutant embryos at 6 dpf, as well as in wild-type embryos at 4 dpf. The numbers of neuromasts analyzed for each staining were 12, 13, and 10 for control, double mutant, and wild type embryos at 4 dpf, respectively.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	prps1b^hg19/hg19; prps1a^{la015591Tg/la015591Tg}
Observed In:	neuromast hair cell cytoskeleton of presynaptic active zone neuromast hair cell synapse
Stage:	Day 6

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Sci. Rep.