FIGURE

Fig. 5

ID

ZDB-FIG-170419-5

Publication

Ki et al., 2017 - Overexpression of PDGFRA cooperates with loss of NF1 and p53 to accelerate the molecular pathogenesis of malignant peripheral nerve sheath tumors

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Fig. 5

Sunitinib retards the progression of primary MPNSTs in transgenic fish with wild-type PDGFRA. (a–f) Images of Tg (sox10:PDGFRA wild-type; sox10:mCherry; nf1a^+/−; nf1b^−/−; p53^m/m) zebrafish with primary MPNSTs before drug treatment. mCherry driven by the sox10 promoter is expressed by the tumor cells. Fish with MPNSTs were incubated in 2 μm of sunitinib (n=3) or DMSO (n=3) in the fish water for 10 days. (g–l) After drug treatment, tumor images were taken under the same condition as before treatment. (m) Comparison of cross-sectional areas of MPNSTs after sunitinib treatment and the DMSO control shows that the tumors increase in size when treated with the DMSO vehicle, and that this growth appears to be retarded by sunitinib treatment (P<0.05).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tp53^zdf1/zdf1; nf1a^p301/+; nf1b^p303/p303; zdf26Tg; zdf28Tg
Condition:	chemical treatment by environment: sunitinib
Observed In:	whole organism neurofibrosarcoma
Stage:	Adult

Phenotype Detail

Acknowledgments

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