FIGURE

Fig. 7

ID

ZDB-FIG-160315-12

Publication

Samuel et al., 2016 - Six3 regulates optic nerve development via multiple mechanisms

Other Figures

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Fig. 7

Delayed differentiation of RGCs in Six3-deficient retinas.

(A-L) Eyes in whole embryos (A-F) or dissected eyes (G-L). (A,B) zn-5 immunohistochemistry of eyes in normal (A) and Six3-deficient embryos (B). Arrow in (B) points at the anterior-ventral region lacking differentiated RGCs. (C-F) WISH for cxcr4b at 30 hpf (C,D) and 48 hpf (E,F) in normal (C,E) and Six3-deficient (D,F) retinas. (G-J) WISH for isl1 at 35 hpf (G,H) and 48 hpf (I,J) in normal (G,I) and Six3-deficient (H,J) retinas. Asterisk in H marks remnants of tissues outside the eye, which was dissected. (K-L) WISH for robo2 at 48 hpf in normal (K) and Six3-deficient (L) retinas. Arrows in (K,L) point at RGCs that express robo2. All panels are lateral views, anterior to the left. Scale bars are 50 µm.

Expression Data

Genes:	cxcr4b isl1a robo2
Antibody:	zn-5
Fish:	AB/TL six3a^vu129/vu129; six3b^vu87/vu87 (AB/TL)
Anatomical Terms:	eye retinal ganglion cell retinal ganglion cell axon
Stage Range:	Prim-15 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	six3a^vu129/vu129; six3b^vu87/vu87 (AB/TL)
Observed In:	eye retinal ganglion cell neuron differentiation
Stage Range:	Prim-15 to Long-pec

Phenotype Detail

Acknowledgments

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