Gene
cxcr4b
- ID
- ZDB-GENE-010614-1
- Name
- chemokine (C-X-C motif), receptor 4b
- Symbol
- cxcr4b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Exhibits G protein-coupled chemoattractant receptor activity. Involved in several processes, including gamete generation; nervous system development; and regulation of chemotaxis. Localizes to plasma membrane. Human ortholog(s) of this gene implicated in WHIM syndrome; hematologic cancer (multiple); leukopenia; osteoporosis; and pancreatic adenocarcinoma. Is expressed in several structures, including anterior neural keel; immature eye; mesoderm; nervous system; and neurogenic placode. Orthologous to human CXCR4 (C-X-C motif chemokine receptor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 115 figures from 83 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb403 (56 images)
Wild Type Expression Summary
- All Phenotype Data
- 25 figures from 18 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| WHIM syndrome 1 | Alliance | Myelokathexis, isolated | 193670 |
| WHIM syndrome 1 | Alliance | WHIM syndrome 1 | 193670 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Chemokine receptor family | CXC chemokine receptor 4/atypical chemokine receptor 2 | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|
|
UniProtKB:Q9PTF7
|
353 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cxcr4b-201
(1)
|
Ensembl | 1,674 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-cxcr4b | monoclonal | Mouse |
|
2 |
Plasmids