FIGURE

Fig. 1

ID

ZDB-FIG-160304-41

Publication

Takacs et al., 2016 - miR-430 regulates oriented cell division during neural tube development in zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Fig. 1

miR-430 is required for neural tube morphogenesis. Transverse sections through the hindbrain region of 20-somite stage embryos. Topro3, nuclear stain. Wildtype neural progenitors (A, D and H) display apical localization of aPKC and bilateral organization along the presumptive neural midline (A), display normal subcellular localization of F-actin (D), and acquire elongated cell morphology (H). In contrast, MZdicer neural progenitors (B, E and I) form ectopic apical membranes (B), display abnormal F-action organization (E), and fail to establish contact with lateral membrane and acquire epithelial character in dorsal regions (I). (C, F and J) Neural progenitors from MZdicer embryos injected at the 1-cell stage with miR-430 RNA duplex display rescued cell morphology and organization. (G) Scatter labeling strategy. 1-2 blastomeres of 16-cell embryos were injected with GFP mRNA.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 409(2), Takacs, C.M., Giraldez, A.J., miR-430 regulates oriented cell division during neural tube development in zebrafish, 442-50, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.