FIGURE

Fig. 8

ID

ZDB-FIG-160208-57

Publication

Matrone et al., 2015 - CDK9 and its repressor LARP7 modulate cardiomyocyte proliferation and response to injury in the zebrafish heart

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Fig. 8

Rescue of the Cdk9-knockdown phenotype using capped cdk9 mRNA or Larp7-Mo-SB. (A–C) Survival and phenotype score in embryos treated with CDK9-Mo-SB (Cdk9-Mo), LARP7-Mo-SB (Larp7-Mo), CDK9-Mo-SB+cdk9 mRNA, Cdk9-Mo-SB+Larp7-Mo-SB assessed independently during the first 120hpf (n=3 experiments, n>50 embryos per group). (D) Effects of rescuing the Cdk9-knockdown phenotype (cdk9 mRNA or Larp7-Mo-SB) on recovery of the cardiac function after laser injury (N=3, n=20–30 embryos per experiment). Two-way ANOVA and Bonferroni post-hoc test; ns, non-significant; *P<0.05, **P<0.01 and ***P<0.001. Means±s.e.m. are shown in B, C and D.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	f1Tg + MO3-cdk9 f1Tg + MO2-larp7 + MO3-cdk9
Knockdown Reagents:	MO2-larp7 MO3-cdk9
Observed In:	cardiac muscle contraction cardiac muscle tissue regeneration heart whole organism
Stage Range:	Prim-5 to Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cell Sci.