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ZDB-FIG-160208-12

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Pinto et al., 2016 - Lxr regulates lipid metabolic and visual perception pathways during zebrafish development

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Fig. 1

The LXR ligands T0901317 and GW3965 activate zfLxr and affect gene expression in zebrafish larvae. Transactivation assays performed in HG5LN cells stably transfected with chimeric GAL4-zfLxr LBD in the presence of increasing concentrations of T0901317 and GW3965. Results are presented as mean ± s.d. of 3 independent experiments. (A) Heat map of differentially expressed genes in 6 dpf zebrafish larvae exposed to T0901317 or GW3965 as determined by microarray analysis (absolute fold change e |±1.4|, FDR-adjusted P≤0.05) (B). Venn diagram illustrating the number of statistically significant genes that were co-regulated in zebrafish larvae treated with T0901317 or GW3965 (C).

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Reprinted from Molecular and Cellular Endocrinology, 419, Pinto, C.L., Kalasekar, S.M., McCollum, C.W., Riu, A., Jonsson, P., Lopez, J., Swindell, E., Bouhlatouf, A., Balaguer, P., Bondesson, M., Gustafsson, J.Å., Lxr regulates lipid metabolic and visual perception pathways during zebrafish development, 29-43, Copyright (2016) with permission from Elsevier. Full text @ Mol. Cell. Endocrinol.