FIGURE

Fig. 5

ID

ZDB-FIG-151207-10

Publication

Yuan et al., 2015 - CCAAT/enhancer-binding protein α is required for hepatic outgrowth via the p53 pathway in zebrafish

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Fig. 5

The p53 signaling pathway is activated in cebpa-deficient developing liver.

(A–B) Quantitative PCR analysis of the expression of cell proliferation and apoptosis-related genes in 72 hpf embryos. Data shown are the mean ± SD, n e 3, *P < 0.05 by student’s t-test. (C,E) WISH assay of lfabp at 72 hpf. Loss of p53 could rescue the hepatic defect in cebpa mutant embryos. Dorsal views with anterior to the top. (D,F) The relative liver area measured in (C,E) respectively. The result shown is fold difference compared with the level (set to 100) detected in control embryos (mean ± SD, n e 3, **P < 0.005 by student’s t-test).

Expression Data

Genes:	bcl2a bcl2l1 fabp1a jun mycb
Fish:	WT cebpa^rj31/rj31 cebpa^rj31/+ cebpa^rj31/+ + MO7-tp53 tp53^zdf1/zdf1; cebpa^rj31/rj31
Knockdown Reagent:	MO7-tp53
Anatomical Terms:	liver whole organism
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cebpa^rj31/rj31 cebpa^rj31/+ cebpa^rj31/+ + MO7-tp53 tp53^zdf1/zdf1; cebpa^rj31/rj31
Knockdown Reagent:	MO7-tp53
Observed In:	intrinsic apoptotic signaling pathway by p53 class mediator liver liver development whole organism
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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