Gene
mycb
- ID
- ZDB-GENE-040426-780
- Name
- MYC proto-oncogene, bHLH transcription factor b
- Symbol
- mycb Nomenclature History
- Previous Names
-
- cmycb
- C-Myc2 (1)
- zgc:55680
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in definitive hemopoiesis and hematopoietic progenitor cell differentiation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); demyelinating disease; hematologic cancer (multiple); prostate cancer (multiple); and urinary bladder cancer. Is expressed in several structures, including caudal vein plexus; intestine; nervous system; presumptive neural retina; and shield. Orthologous to human MYC (MYC proto-oncogene, bHLH transcription factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 29 figures from 21 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Lin et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Burkitt lymphoma | Alliance | Burkitt lymphoma, somatic | 113970 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003327 | Leucine zipper, Myc |
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR012682 | Transcription regulator Myc, N-terminal |
| Family | IPR002418 | Transcription regulator Myc |
| Family | IPR050433 | Myc family transcription factors |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Helix-loop-helix DNA-binding domain superfamily | Leucine zipper, Myc | Myc family transcription factors | Myc-type, basic helix-loop-helix (bHLH) domain | Transcription regulator Myc | Transcription regulator Myc, N-terminal |
|---|---|---|---|---|---|---|---|
|
UniProtKB:B2GQB7
|
396 | ||||||
|
UniProtKB:Q7ZVS9
|
396 |
Interactions and Pathways
No data available
Plasmids
No data available