FIGURE

Fig. S1

ID

ZDB-FIG-151030-6

Publication

Antonio et al., 2015 - The wound inflammatory response exacerbates growth of pre-neoplastic cells and progression to cancer

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Fig. S1

Standard larval model for studying immune cell:pre-neoplastic cell interactions.

A. Schematic to illustrate the larval model, whereby oncogenic Human RasG12V is used to drive cell transformation in a tissue specific manner, in melanocytes and mucus-secreting goblet cells by a kit-a enhancer trap (ET30).

B. DIC microscopy of a 5dpf kita:RasG12VeGFP zebrafish larvae.

C. Confocal laser scanning microscopy image of a 5dpf kita:RasG12VeGFP; LysC:dsRed zebrafish larvae. (A′, B′, C′) Zoom in of the area around the cloaca to illustrate the region frequently imaged.

D. and E Adult fish occasionally develop large pigmented tumours, particularly at exposed sites such as the ventral fin by the cloaca or tail.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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