FIGURE

Fig. 6

ID

ZDB-FIG-151030-17

Publication

Miesfeld et al., 2015 - Yap and Taz regulate retinal pigment epithelial cell fate

Other Figures

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Fig. 6

Cell death and proliferation are normal in yap^-/- eyes. (A) The numbers of dying cells identified by Acridine Orange staining do not differ in yap^-/- mutants at 14 (P=0.8465), 18 (P=0.6542) or 24 (P=0.2558) hpf as compared with wild type. Numbers of eyes analyzed: 14hpf, wt n=31, yap^-/- n=5; 18hpf, wt n=39, yap^-/- n=10; 24hpf, wt n=24, yap^-/- n=16. (B) Eye field mitotic cell counts do not differ between yap^+/^? (wt) and yap^-/- at 14 (P=0.9205), 18 (P=0.4329) and 24 (P=0.2222) hpf. Numbers of eyes analyzed: 14hpf, wt n=38, yap^-/- n=6; 18hpf, wt n=38, yap^-/- n=6; 24hpf, wt n=36, yap^-/- n=6. (C-E′′′) Time-course of expression of tfec:eGFP in prospective RPE cells. (F) Mitotic cell counts of tfec:eGFP⁺ cells do not differ between wild-type and yap^-/- eyes at 14hpf (P=0.5408). Numbers of eyes analyzed: wt n=18, yap^-/- n=6. P-values were obtained using an unpaired t-test with equal s.d. Error bars indicate s.e.m. Wild type included full RPE coverage, whereas yap^-/- showed some RPE loss.

Expression Data

Gene:	EGFP
Fish:	mw68Tg
Anatomical Term:	optic vesicle
Stage Range:	10-13 somites to 14-19 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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