FIGURE

Fig. 7

ID

ZDB-FIG-151002-12

Publication

Liu et al., 2015 - Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia

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Fig. 7

Enhanced vascular lipid accumulation in apoc2 mutants. (A,B) TG and TC levels in homogenates of 14dpf WT and apoc2 mutant (mut) larvae, normalized to total protein content. Larvae were fed a normal diet. Results are mean±s.e.m.; n=3 in each group; *P<0.05; ***P<0.001 (Student′s t-test). (C,D) Vascular lipid deposits in 14dpf WT (n=8) and apoc2 mutant (n=8) larvae fed a normal diet; **P<0.01 (Student′s t-test). (E) Colocalization of vascular lipid deposits with macrophages in 14dpf apoc2 mutant mpeg1:EGFP zebrafish. (F) Quantification of lipid deposits associated and non-associated with macrophages in apoc2 mutant larvae. Results are mean±s.e.m.; n=7. Scale bars: 50µm.

Expression Data

Gene:	EGFP
Fish:	apoc2^sd38/sd38; gl22Tg
Anatomical Term:	macrophage
Stage:	Days 14-20

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	apoc2^sd38/sd38 apoc2^sd38/sd38; gl22Tg
Observed In:	anatomical structure cholesterol anatomical structure triglyceride macrophage lipid trunk vasculature lipid
Stage:	Days 14-20

Phenotype Detail

Acknowledgments

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