FIGURE

Fig. S7

ID

ZDB-FIG-150810-18

Publication

Evason et al., 2015 - Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish

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Fig. S7

SP600125 and amitriptyline do not significantly affect fabp10a promoter activity or Wnt reporter activity.

(A) Representative photographs of fabp10a:EGFP expression (the same fabp10a promoter element used to drive pt-β-cat expression) in control (top row) and Tg(fabp10a:pt-β-cat) (bottom row) zebrafish livers at 5 dpf. (B) Fluorescence intensity ± standard error of the mean (SEM) was quantified using ImageJ, and samples were compared using 2-way ANOVA; p>0.05 for each group compared to every other group. N values are shown above the x-axis. (C) Representative photographs of 7xTCF-Xla.Siam:GFP (Wnt reporter) expression in control (top row) and Tg(fabp10a:pt-β-cat) (bottom row) zebrafish livers at 6 dpf. (D) Fluorescence intensity ± standard error of the mean (SEM) was quantified using ImageJ, and samples were compared using 2-way ANOVA (p>0.05 for all drug treatments compared to DMSO control of same genotype.) Scale bars, 20 µm. Six zebrafish were analyzed for each group.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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