FIGURE

Fig. S2

ID

ZDB-FIG-150708-8

Publication

Sato et al., 2015 - Neuregulin 1 Type II-ErbB Signaling Promotes Cell Divisions Generating Neurons from Neural Progenitor Cells in the Developing Zebrafish Brain

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Fig. S2

Generation of post-mitotic neurons is impaired in the optic tectum by treatment with an ErbB inhibitor AG1478.

A. Impaired generation of post-mitotic neurons in the optic tectum (OT; dotted circle) at 48 hpf following AG1478 treatment in TgBAC(neurod:EGFP) embryos, shown in a lateral view. Scale bar, 100 µm. B. Decreased neurod:EGFP-positive post-mitotic neurons and accumulated -8.4neurog1:nRFP-positive NPCs at 48 hpf by AG1478 treatment. A, apical; B, basal; NL, neuronal layer; SVZ, sub-ventriular zone; VZ, ventricular zone. Scale bar, 10 µm. C. Quantification of neurod:EGFP intensity in the OT for the experiment shown in A (mean ± s.e.m.; *P < 0.05, unpaired t test; n = 4–5).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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