FIGURE

Fig. 4

ID

ZDB-FIG-150406-44

Publication

Sun et al., 2015 - Myc-Induced Liver Tumors in Transgenic Zebrafish Can Regress in tp53 Null Mutation

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Fig. 4

Development of multinodular HCC in late stage of mifepristone induction.

MycAG fish were induced by 2 µM mifepristone from 1 mpf and sampled at 9 mpf (8 mpi) for gross observation, histological examination and immunocytochemistry. (A–D) Gross observation of multinodular HCC in two examples of mycAG fish in both bright field and GFP channel. (E) Confocal microscope image to show GFP positive hepatocytes and GFP negative cirrhosis stroma. (F,G) H&E staining of multinodular HCC sections with two different magnifications. (H,I) Immunocytochemical staining of E-cadherin in liver sections from a Driver fish (H) and a mycAG fish (I). (J,K) Immunocytochemical staining of β-catenin in liver sections from a Driver fish (J) and a mycAG fish (K).

Expression Data

Gene:	EGFP
Antibodies:	Ab6-cdh1 Ab13-ctnnb
Fish:	gz23Tg gz23Tg; gz27Tg
Condition:	chemical treatment: pharmaceutical
Anatomical Terms:	hepatocyte hepatocyte membrane hepatocyte nucleus liver
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gz23Tg; gz27Tg
Condition:	chemical treatment: pharmaceutical
Observed In:	liver liver hepatic tumor
Stage:	Adult

Phenotype Detail

Acknowledgments

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