FIGURE

Fig. 4

ID

ZDB-FIG-150216-5

Publication

Joya et al., 2014 - Transient Exposure to Ethanol during Zebrafish Embryogenesis Results in Defects in Neuronal Differentiation: An Alternative Model System to Study FASD

Other Figures

All Figure Page

Back to All Figure Page

Fig. 4

Effects of ethanol in specific neuronal populations

Analysis of Tg[Isl3:GFP] non-exposed embryos (A-B) and exposed to ethanol (C-D) expressing GFP in the primary sensory neurons. (E-G) Tg[neurog1:GFP] embryos treated with ethanol display a graded phenotype: (E) Phenotype I embryos showed a normal development with high levels of GFP along the CNS, (F) Phenotype II embryos showed a delay in their development but displayed normal levels of GFP, and (G) Phenotype III, which has a very short body axis and GFP levels not grossly affected. (H) Quantification of GFP-positive sensory neurons in specific hemisegments. Note the decrease in the number of Isl3:GFP neurons per hemisegment in the ethanol-treated embryos. (I) Quantification of the penetrance of the phenotype in Tg[neurog1:GFP] embryos. ** p<0.005 vs. control group.

Expression Data

Genes:	EGFP GFP
Fish:	w61Tg zc7Tg
Condition:	chemical treatment: ethanol
Anatomical Terms:	central nervous system cranial ganglion sensory neuron spinal cord sensory neuron
Stage Range:	Prim-5 to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	zc7Tg
Condition:	chemical treatment: ethanol
Observed In:	sensory neuron spinal cord
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One