FIGURE

Fig. 4

ID

ZDB-FIG-150120-9

Publication

Solomon et al., 2002 - Concerted action of two dlx paralogs in sensory placode formation

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Fig. 4

Expression of otic and olfactory differentiation markers is reduced by loss of dlx3 and dlx7 function. (A,G,M) Wild-type, (B,H,N) control MO, (C,I,O) dlx7 MO, (D,J,P) dlx3 MO, (E,K,Q) dlx3+7 MO and (F,L,R) b380 mutant embryos. (A-L) Expression of eya1 at 18 somites in (A-F) whole-mount and (G-L) flat-mount embryos. (M-R) Flat-mount in situ hybridization with anxV at 24 hours. (A-F) Lateral views, anterior towards the left. (G-R) Dorsal view, anterior towards the top of the panels. ot, otic vesicle; olf, olfactory placode; ap, anterior pituitary. Scale bars: in A, 100 µm in A-F; in G, 25 µm in G-L; in M, 25 µm in M-R.

Expression Data

Genes:	anxa5b eya1
Fish:	WT WT + MO2-dlx3b WT + MO4-dlx4b WT + MO5-dlx3b WT + MO5-dlx4b WT + MO2-dlx3b + MO4-dlx4b WT + MO2-dlx3b + MO5-dlx4b WT + MO4-dlx4b + MO5-dlx3b WT + MO5-dlx3b + MO5-dlx4b Df(Chr12:dlx3b,dlx4b,tbx6)b380/b380
Knockdown Reagents:	MO2-dlx3b MO4-dlx4b MO5-dlx3b MO5-dlx4b
Anatomical Terms:	anterior lateral line placode olfactory placode otic placode otic vesicle posterior lateral line placode somite
Stage Range:	14-19 somites to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO2-dlx3b WT + MO5-dlx3b WT + MO2-dlx3b + MO4-dlx4b WT + MO2-dlx3b + MO5-dlx4b WT + MO4-dlx4b + MO5-dlx3b WT + MO5-dlx3b + MO5-dlx4b Df(Chr12:dlx3b,dlx4b,tbx6)b380/b380
Knockdown Reagents:	MO2-dlx3b MO4-dlx4b MO5-dlx3b MO5-dlx4b
Observed In:	olfactory placode development otic vesicle development
Stage Range:	14-19 somites to Prim-5

Phenotype Detail

Acknowledgments

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