FIGURE

Fig. S7

ID

ZDB-FIG-150116-4

Publication

Kizil et al., 2014 - Simplet/Fam53b is required for Wnt signal transduction by regulating β-catenin nuclear localization

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Fig. S7

Loss of Wnt activity not due to defects in cell proliferation, Related to Figure 1. (A) Immunostaining for histone-3 phosphorylation (H3P) in MM-control embryos (mismatch) at 95% epiboly. (B) H3P staining is reduced in same-staged smp morphants (antisense). (C) H3P staining is decreased in embryos treated with hydroxyurea (HU) and aphidicolin (AC). (D) Graph indicates the relative mitotic indices of mismatch controls (black), smp morphant (grey) and HU/AC-treated embryos (white) through development. (E) 7xTCF-siam:mCherry activity in control embryos. (F) Activity of the Wnt-reporter in smp morphants. (G) Wnt-reporter activity in HU/AC-treated embryos. Scale bars equal 100 μm. “***” is p < 0.005.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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