FIGURE

Fig. S1

ID

ZDB-FIG-140910-26

Publication

Apschner et al., 2014 - Pathological mineralization in a zebrafish enpp1 mutant exhibits features of Generalized Arterial Calcification of Infancy (GACI) and Pseudoxanthoma Elasticum (PXE)

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Fig. S1

Van kossa/van Gieson staining shows segmented mineralization of the notochord sheath in siblings (A), in dgf mutants show ectopic calcification of the intervertebral spaces (B). Transverse section through the neuraltube of sibling (C) and mutant with ectopic calcification (D). Alizarin red/Alcian blue stained cleithrum and pectoral fin cartilage of siblings (E) and dgf mutant (D) showing ectopic calcification. Overview of Alizarin red/Alcian blue stained sibling (G) and mutant (H). The black arrowheads indicate cranial calcifications, the red arrowheads point at mineralizations of the skin surrounding the yolk sac and heart (H). dgf mutants can reach adulthood in rare cases but remain smaller (I). Transverse section of alizarin stained juvenile embryos at the bulbus arteriosos (b. a.), no mineralization is visible in silbing (J), circumferential calcification in the dgf mutant (K).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	enpp1^{hu4581/hu4581}
Observed In:	ball integument bulbus arteriosus cleithrum cranium neural tube notochord outer sheath cell notochord outer sheath cell bone mineralization pectoral fin cartilage whole organism
Stage Range:	Day 4 to Days 45-89

Phenotype Detail

Acknowledgments

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