FIGURE

Fig. 6

ID

ZDB-FIG-140822-63

Publication

Rost et al., 2014 - Hyaluronic acid receptor Stabilin-2 regulates Erk phosphorylation and arterial--venous differentiation in zebrafish

Other Figures

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Fig. 6

Stab2 and Has2 combinatorial knockdown results in a synergistic inhibitory effect on ISV formation.

(A–C) A subphenotypic 1.25 ng dose of Stab2 (B) and 8 ng dose of Has2 (C) morpholinos do not affect vascular development when injected alone. (D) In contrast, Stab2 and Has2 MO co-injection results in 51 percent of embryos that lack ISVs suggesting that Stab2 and HA genetically interact. Arrows indicate ISVs. (E) Graph shows percentages of embryos displaying reduced or absent ISVs. Lateral view of 24 hpf embryos, anterior is to the left.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	y1Tg + MO3-has2 y1Tg + MO1-stab2 + MO3-has2 + MO4-stab2 + MO4-tp53
Knockdown Reagents:	MO1-stab2 MO3-has2 MO4-stab2 MO4-tp53
Observed In:	intersegmental vessel vasculature development
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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