FIGURE

Fig. 5

ID

ZDB-FIG-140811-36

Publication

Ju et al., 2014 - Activation of Sonic hedgehog signaling in neural progenitor cells promotes glioma development in the zebrafish optic pathway

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Fig. 5

Mdm2 expression in zOPGs. (a) In a cryosection of an eye tumor, Mdm2 was overexpressed in the sparsely nucleated glioma region, but not in the densely nucleated neural retinal tumor. (b) Immunofluorescence of a wild-type fish retina showed some overlap of Mdm2 and GFAP expression in Müller glial cells in the ONH. Insert shows close-up of staining. (c) In a transverse cryosection from a fish with asymmetric optic tectum development, the enlarged tectal lobe stained positive for Mdm2, but the contralateral lobe showed little staining. (d) Specific Mdm2 staining could be blocked by the Mdm2 immunizing peptide. OT, optic tectum.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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