FIGURE

Fig. 1

ID

ZDB-FIG-140807-55

Publication

Ma et al., 2014 - The asparaginyl endopeptidase legumain is essential for functional recovery after spinal cord injury in adult zebrafish

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Fig. 1

Legumain mRNA expression is upregulated in brainstem neurons during the axonal regrowth phase after SCI.

(A) In situ hybridization was performed to study the expression of legumain in the NMLF and IMRF. Representative images depict legumain-positive cells in the NMLF and IMRF 11 days after SCI. More positive cells for legumain mRNA are observed in the NMLF and IMRF after SCI when compared with sham-injured control. With the sense control probe, no signal is observed. (B, C) Quantification shows that legumain mRNA expression is slightly upregulated in the NMLF and IMRF at 3 days and highly upregulated at 11 days after SCI. The expression patterns of legumain in the NMLF and IMRF are similar. Dorsal is up. NMLF, n = 6 fish; IMRF, n = 3 fish. * P<0.05, two-tailed t-test; mean values ±SEM are shown. Scale bar, 50 μm.

Expression Data

Gene:	lgmn
Fish:	WT
Condition:	transection: spinal cord
Anatomical Terms:	hindbrain intermediate reticular formation nucleus of the medial longitudinal fasciculus medulla oblongata
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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