FIGURE

Fig. 3

ID

ZDB-FIG-140714-45

Publication

Stawicki et al., 2014 - The zebrafish merovingian mutant reveals a role for pH regulation in hair cell toxicity and function

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Fig. 3

Uptake of FM1-43 and hair cell toxicants are reduced in merovingian mutants. (A) There is reduced uptake of FM1-43 into the hair cells of merovingian mutants. Hair cells are expressing the brn3c:gfp transgene. (B) Neomycin-TR fails to enter hair cells of merovingian mutants. (C) Rho-Pt uptake is reduced in merovingian mutants. (D) Quantification of FM1-43, neomycin-TR, and Rho-Pt uptake into hair cells, normalized to background fluorescence (n=10 fish); **P=0.0046, ***P<0.0001 for neomycin-TR and P=0.0006 for Rho-Pt by Student’s t-test, Welch’s correction was used for neomycin-TR and Rho-Pt. Error bars indicate s.d. Scale bars: 10 μm.

Expression Data

Gene:	GFP
Fish:	gcm2^w40/w40; s356tTg
Condition:	chemical treatment: pharmaceutical
Anatomical Term:	neuromast hair cell
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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