FIGURE

Fig. 2

ID

ZDB-FIG-140714-44

Publication

Stawicki et al., 2014 - The zebrafish merovingian mutant reveals a role for pH regulation in hair cell toxicity and function

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Fig. 2

merovingian mutants are resistant to toxicant-induced hair cell death. (A) Quantification of lateral line hair cell number in wild-type siblings and merovingian mutants; ***P<0.0001 by Student’s t-test (n=10 fish). (B) Hair cells labeled with parvalbumin in merovingian mutants and wild-type siblings without (left) and with (right) neomycin treatment. merovingian mutants show reduced initial hair cell numbers, but no hair cell loss in response to neomycin. (C) merovingian mutants show a significant resistance to neomycin-induced hair cell death; P<0.0001 by two-way ANOVA (n=10 fish). (D) merovingian mutants are partially resistant to cisplatin-induced hair cell death. Genotypes are significantly different; P<0.0001 by two-way ANOVA (n=6–10 fish). Error bars indicate s.d. Scale bar: 10 μm.

Expression Data

Antibody:	Ab1-pvalb
Fish:	WT gcm2^w40/w40 (AB)
Condition:	chemical treatment: pharmaceutical
Anatomical Term:	neuromast hair cell
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gcm2^w40/w40 (AB)
Observed In:	neuromast hair cell
Stage:	Day 5

Phenotype Detail

Acknowledgments

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