FIGURE

Fig. 3

ID

ZDB-FIG-140512-53

Publication

Jones et al., 2013 - Modelling human Wiskott-Aldrich syndrome protein mutants in zebrafish larvae using live in vivo imaging

Other Figures

All Figure Page

Back to All Figure Page

Fig. 3

WASp mutant larvae show increased susceptibility to death from bacterial infection. (A) Ratio of genotypes of the offspring from WASp heterozygous in-crossed adults at 5dpf and 3 months. Values in brackets indicate percentage drop in survival from predicted Mendelian ratio for WASp^+/- and WASp^-/- larvae. (B) Survival curves for WT (n = 44) versus mutant (n = 43) zebrafish larvae injected at 52hpf with S. aureus; control injection is with PBS, WT (n = 15) mutant (n = 18). (C) Colony-forming unit (cfu) counts of individual larvae injected with 1200cfu of S. aureus at (i) 4hours post injection (hpi), WT (n = 8), mutant (n = 8); (ii) 10hpi, WT (n = 16), mutant (n = 15); (iii) 24hpi, WT (n = 10), mutant (n = 10). Error bars (s.d); asterisks denote significance values of *P<0.05, **P<0.01 using Student′s t-test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	wasb^{hu3280/hu3280}
Condition:	bacterial treatment
Observed In:	whole organism
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cell Sci.