FIGURE

Fig. 7

ID

ZDB-FIG-140331-2

Publication

Wilkins et al., 2013 - p53-Mediated Biliary Defects Caused by Knockdown of cirh1a, the Zebrafish Homolog of the Gene Responsible for North American Indian Childhood Cirrhosis

Other Figures

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Fig. 7

Normal ribosomal RNA processing in Cirhin-deficient larvae.

(A) Northern blots demonstrating equivalent levels of pre-rRNA species in duplicate samples of mismatch MO-injected and cirh1a MO-injected embryos. Dashes and letters correspond to presumed pre-rRNA species identified by probes 5′ETS, ITS1, and ITS2, while asterisks indicate unknown pre-rRNA species (schematized in panel B). The far right panel shows the results of blotting with an 18S rRNA probe, demonstrating total RNA loading. Mean 45S/18S rRNA ratios were not statistically different between treatment groups (p>0.05). (B) Schematic depicting presumed pathway of zebrafish ribosomal RNA processing; individual RNA species not drawn to scale (adapted from [32]).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-utp4 WT + MO2-utp4
Knockdown Reagents:	MO1-utp4 MO2-utp4
Observed In:	rRNA processing
Stage:	20-25 somites

Phenotype Detail

Acknowledgments

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