FIGURE

Fig. 6

ID

ZDB-FIG-140325-57

Publication

Varga et al., 2001 - Zebrafish smoothened functions in ventral neural tube specification and axon tract formation

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Fig. 6

Hh signaling patterns the midline of the anterior neural plate. (A,B) expression of zic1 at tailbud stage in wild-type (A) and smu^b641 mutant (B) embryos. (C,D) expression of foxb1.2 at tailbud stage in wild-type (C) and smu^b641 mutant (D) embryos. Arrows indicate location of hypothalamic precursors demarcated by foxb1.2. (E, F) Head morphology of wild-type (E) and smub641 mutant (F) embryos. In 48 h smu mutants, the hypothalamus was reduced in size, consistent with reduced foxb1.2 expression in neural plate precursors and subsequent progressive loss of hypothalamic tissue. (A-D) Dorsal views of prospective head region, anterior towards top. (E,F) Ventral views, anterior towards top. Scale bar: 200 μm in A-D; 135 μm in E,F.

Expression Data

Genes:	foxb1a zic1
Fish:	WT smo^b641/b641 (AB)
Anatomical Terms:	neural plate optic primordium
Stage:	Bud

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	smo^b641/b641 (AB)
Observed In:	eye
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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