FIGURE

Fig. 6

ID

ZDB-FIG-140320-20

Publication

Essner et al., 2000 - Mesendoderm and left-right brain, heart and gut development are differentially regulated by pitx2 isoforms

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Fig. 6

pitx2a and pitx2c are differentially expressed during the asymmetric development of the diencephalon, gut and heart. In situ hybridizations at 22-25 somites of development using a full-length pitx2 probe (A,D,G,J), a pitx2a isoform specific probe (B,E,H,K) and a pitx2c isoform specific probe (C,F,I,L). (A-C) Lateral views with arrows pointing to asymmetric expression in the dorsal diencephalon, the developing heart and gut from anterior to posterior. (D-F) Frontal views; arrows mark left-sided asymmetric expression in the dorsal diencephalon. Both isoforms were expressed symmetrically in the ventral diencephalon. (G-I) Dorsal views with arrows marking left-sided expression in the developing gut. (G-I) Double in situ hybridization with pitx2 or pitx2-isoform specific probes (blue) and lft2 (red) probes showing asymmetric expression of pitx2 and lft2 in the heart field.

Expression Data

Genes:	lft2 pitx2
Fish:	WT
Anatomical Terms:	diencephalon dorsal side diencephalon left side diencephalon ventral side gut gut left side heart rudiment heart rudiment left side Rohon-Beard neuron
Stage:	20-25 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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