FIGURE

Fig. S1

ID

ZDB-FIG-140211-46

Publication

Bräutigam et al., 2013 - Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1

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Fig. S1

Knockdown of zfGrx2 does not induce gross changes in morphology of zebrafish embryos. (A) At 48 hpf, fli:EGFP transgenic embryos displayed malformation (arrows) of the fluorescent vasculature after morpholino induced knockdown of zfGrx2. The overall morphology was unaffected by the loss of zfGrx2. (Scale bar, 200 μm.) (B) Densitometric analyses of three Western blots revealed significant down-regulation of zfGrx2 at 48 hpf after morpholino injection. (C) Visualization of cell death by Acridine Orange staining in fli:EGFP control embryos and zfGrx2 knockdown embryos with confirmed defects in vessel formation 48 hpf. (Scale bars, 100 μm.)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA